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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion.
Lan Y, Moustafa M, Knoll M, Xu C, Furkel J, Lazorchak A, Yeung TL, Hasheminasab SM, Jenkins MH, Meister S, Yu H, Schlegel J, Marelli B, Tang Z, Qin G, Klein C, Qi J, Zhou C, Locke G, Krunic D, Derner MG, Schwager C, Fontana RE, Kriegsmann K, Jiang F, Rein K, Kriegsmann M, Debus J, Lo KM, Abdollahi A. Lan Y, et al. Among authors: fontana re. Cancer Cell. 2021 Oct 11;39(10):1388-1403.e10. doi: 10.1016/j.ccell.2021.08.008. Epub 2021 Sep 9. Cancer Cell. 2021. PMID: 34506739 Free article.
p53 controls choice between apoptotic and non-apoptotic death following DNA damage.
Honeywell ME, Isidor MS, Harper NW, Fontana RE, Cruz-Gordillo P, Porto SA, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. Honeywell ME, et al. Among authors: fontana re. bioRxiv [Preprint]. 2023 May 16:2023.01.17.524444. doi: 10.1101/2023.01.17.524444. bioRxiv. 2023. PMID: 36712034 Free PMC article. Preprint.
Functional genomic screens with death rate analyses reveal mechanisms of drug action.
Honeywell ME, Isidor MS, Harper NW, Fontana RE, Birdsall GA, Cruz-Gordillo P, Porto SA, Jerome M, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. Honeywell ME, et al. Among authors: fontana re. Nat Chem Biol. 2024 Mar 13. doi: 10.1038/s41589-024-01584-7. Online ahead of print. Nat Chem Biol. 2024. PMID: 38480981