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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion.
Cancer Cell. 2021 Oct 11;39(10):1388-1403.e10. doi: 10.1016/j.ccell.2021.08.008. Epub 2021 Sep 9.
Cancer Cell. 2021.
PMID: 34506739
Free article.
p53 controls choice between apoptotic and non-apoptotic death following DNA damage.
Honeywell ME, Isidor MS, Harper NW, Fontana RE, Cruz-Gordillo P, Porto SA, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ.
Honeywell ME, et al. Among authors: fontana re.
bioRxiv [Preprint]. 2023 May 16:2023.01.17.524444. doi: 10.1101/2023.01.17.524444.
bioRxiv. 2023.
PMID: 36712034
Free PMC article.
Preprint.
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Functional genomic screens with death rate analyses reveal mechanisms of drug action.
Honeywell ME, Isidor MS, Harper NW, Fontana RE, Birdsall GA, Cruz-Gordillo P, Porto SA, Jerome M, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ.
Honeywell ME, et al. Among authors: fontana re.
Nat Chem Biol. 2024 Mar 13. doi: 10.1038/s41589-024-01584-7. Online ahead of print.
Nat Chem Biol. 2024.
PMID: 38480981
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Drug GRADE: An Integrated Analysis of Population Growth and Cell Death Reveals Drug-Specific and Cancer Subtype-Specific Response Profiles.
Schwartz HR, Richards R, Fontana RE, Joyce AJ, Honeywell ME, Lee MJ.
Schwartz HR, et al. Among authors: fontana re.
Cell Rep. 2020 Jun 23;31(12):107800. doi: 10.1016/j.celrep.2020.107800.
Cell Rep. 2020.
PMID: 32579927
Free PMC article.
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Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β.
Lan Y, Zhang D, Xu C, Hance KW, Marelli B, Qi J, Yu H, Qin G, Sircar A, Hernández VM, Jenkins MH, Fontana RE, Deshpande A, Locke G, Sabzevari H, Radvanyi L, Lo KM.
Lan Y, et al. Among authors: fontana re.
Sci Transl Med. 2018 Jan 17;10(424):eaan5488. doi: 10.1126/scitranslmed.aan5488.
Sci Transl Med. 2018.
PMID: 29343622
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